血清25-(OH)D、IL...者临床特点及治疗效果的关系_朱健清.pdf
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1、发现 CLDN4 能够通过激活 NF B 信号通路促进急性胰腺炎细胞模型的凋亡和自噬。本研究进一步解释了急性胰腺炎发生、发展的分子机制,为急性胰腺炎的诊治提供了新的理论基础。参考文献 1Li H,Lin Y,Zhang L,et al Ferroptosis and its emerging roles in acutepancreatitis J Chin Med J(Engl),2022,135(17):2026 2034 2Han K,Chen S,Song Y,et al Burden of pancreatitis and associatedrisk factors in Chin
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3、ficant Genes andPathways in Acute Pancreatitis via Bioinformatical Analysis J DigDis Sci,2021,66(9):3045 3053 5Sonika U,Goswami P,Thakur B,et al Mechanism of Increased Intes-tinal Permeability in Acute Pancreatitis:Alteration in Tight JunctionProteinsJ J Clin Gastroenterol,2017,51(5):461 466 6Lee PJ
4、,Papachristou GI New insights into acute pancreatitisJ Natev Gastroenterol Hepatol,2019,16(8):479 496 7Tao L,Lin X,Tan S,et al Arrestin1 alleviates acute pancreatitisvia repression of NF Bp65 activationJ J Gastroenterol Hepatol,2019,34(1):284 292 8 Kojima T,Kyuno D,Sawada N Targeting claudin 4 in hu
5、man pancre-atic cancer J Expert Opin Ther Targets,2012,16(9):881 887 9Neesse A,Griesmann H,Gress TM,et al Claudin 4 as therapeutictarget in cancerJ Arch Biochem Biophys,2012,524(1):64 70 10 Maesaka F,Kuwada M,Horii S,et al Hypomethylation of CLDN4Gene Promoter Is Associated with Malignant Phenotype
6、in Urinary Blad-der CancerJ Int J Mol Sci,2022,23(12):6516 11 Michl P,Buchholz M,olke M,et al Claudin 4:a new target forpancreatic cancer treatment using Clostridium perfringens enterotoxin J Gastroenterology,2001,121(3):678 684 12 Umans DS,Hoogenboom SA,Sissingh NJ,et al Pancreatitis and pan-creati
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8、-elle Interaction and microNA egulationJ Oxid Med Cell Longev,2021,2021:8811935 15 Gaman L,Dragos D,Vlad A,et al Phytoceuticals in Acute Pancreati-tis:Targeting the Balance between Apoptosis and NecrosisJ EvidBased Complement Alternat Med,2018,2018:5264592 16 Chen L,Chen Y,Yun H,et al Tetramethylpyr
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12、4695 2023 07 003文章编号:1671 4695(2023)07 0681 05血清 25 (OH)D、IL 6、CD8 与 NMOSD 患者临床特点及治疗效果的关系朱健清蒋小英童玲玲梁霞(玉林市第一人民医院神经内科广西玉林537000)基金项目:广西科技计划项目(编号:2021AA19001)【摘要】目的探讨血清 25 羟基维生素 D 25 (OH)D、白细胞介素 6(IL 6)、CD8 与视神经脊髓炎谱系疾病(NMOSD)患者临床特点及治疗效果的关系。方法选取 2019 年 1 月至 2021 年 12 月在玉林市第一人民医院接受治疗的 NMOSD 患者 92 例作为观察组,同
13、时随机选取健康体检者 92 名作为对照组。比较两组患者血清 25 (OH)D、IL6、CD8 差异,同时分析观察组不同性别、年龄、体重指数、脊髓受累节段数、脊髓受累部位、扩展残疾状态量表(EDSS)评分差异。结果观察组血清 25 (OH)D 为(29 89 7 82)nmol/L,明显低于对照组,而 IL 6 和 CD8 分别为(25 056 68)pg/mL 和(30 32 9 23)%,均明显高于对照组,差异均有统计学意义(P 0 05)。观察组脊髓受累节段数 5 个的患者血清 25 (OH)D 为(25 28 7 25)nmol/L,明显低于脊髓受累节段数5 个的患者,而 IL 6 和
14、CD8 分别为(2865 702)pg/mL 和(3454 917)%,均明显高于脊髓受累节段数5 个的患者,差异均有统计学意义(P 0 05)。观察组 EDSS 评分6 5 分的患者血清 25 (OH)D 为(23 53 8 00)nmol/L,明显低于 EDSS 评分2 5 分和 3 6 分患者,而 IL 6 和 CD8 分别为(30 86 5 60)pg/mL 和(35 54 8 82)%,均明显高于 EDSS 评分2 5 分和 3 6 分患者,差异均有统计学意义(P 0 05)。观察组 EDSS 评分 3 6 分的患者血清 25 (OH)D 为(28 65 8 10)nmol/L,明1
15、86临床和实验医学杂志2023 年 4 月第 22 卷第 7 期显低于 EDSS 评分2 5 分患者,而 IL 6 和 CD8 分别为(25 02 5 34)pg/mL 和(32 20 9 04)%,均明显高于 EDSS评分2 5 分患者,差异均有统计学意义(P 0 05)。观察组血清水通道蛋白 4 抗体(AQP4 IgG)阳性和阴性表达患者血清 25 (OH)D、IL 6、CD8 比较,差异均无统计学意义(P 0 05)。血清 25 (OH)D 与脊髓受累节段数呈负相关(rs=0 338,P 0 05),IL 6、CD8 与脊髓受累节段数呈正相关(rs=0 336、0 401,P 0 05)
16、。血清 25(OH)D 与 EDSS 评分呈负相关(rs=0 445,P 0 05),IL 6、CD8 与 EDSS 评分呈正相关(rs=0 404、0 465,P 0 05)。与治疗前比较,观察组治疗后血清 25 (OH)D 有所升高,而 IL 6 和 CD8 有所降低,差异均有统计学意义(P0 05)。结论血清 25 (OH)D、IL 6、CD8 与 NMOSD 患者脊髓受累节段数、病情严重程度有关。【关键词】25 羟基维生素 D白细胞介素 6CD8视神经脊髓炎谱系疾病临床特点水通道蛋白4 抗体elationship between serum 25 (OH)D,IL 6,CD8and t
17、he clinical characteristics and therapeutic effect of patients with NMOSDZHU Jian qing,JIANG Xiao ying,TONG Ling ling,et al Department of Neurology,Yulin First Peoples Hospital,Yulin Guangxi 537000,China【Abstract】ObjectiveTo investigate the relationship between serum 25 hydroxyvitamin D 25 (OH)D,int
18、erleukin 6(IL 6),CD8 and clinical characteristics and therapeutic effect of patients with neuromyelitis optica pedigree disease(NMOSD)MethodsA total of 92patients with NMOSD who were treated in Yulin First Peoples Hospital from January 2019 to December 2021 were selected as the observationgroup,and
19、92 healthy people were selected as the control group,the differences in serum 25 (OH)D,IL 6,CD8 between the two groups werecompared At the same time,the differences in gender,age,body mass index,number of involved segments of the spinal cord,involved parts ofthe spinal cord,and scores of the Extende
20、d Disability Status Scale(EDSS)in the observation group were analyzed esultsSerum 25 (OH)D in the observation group was(29 89 782)nmol/L,which was significantly lower than that in the control group(P 005),while IL 6and CD8 were(2505 6 68)pg/mL and(3032 9 23)%,respectively,which was significantly hig
21、her than that in the control group,thedifferences were statistically significant(P 005)In the observation group,the serum 25 (OH)D in patients with more than 5 spinal cordinvolved segments was(25 28 7 25)nmol/L,which was significantly lower than the patients number of spinal cord involved segments 5
22、,while IL 6 and CD8 were(28 65 7 02)pg/mL and(34 54 917)%,respectively,which was significantly higher than the patients num-ber of spinal cord involved segments 5,the differences were statistically significant(P 0 05)The serum 25 (OH)D of patients withEDSS score 65 was(2353 800)nmol/L,which was sign
23、ificantly lower than that of patients with EDSS score25 and 3 6,while IL 6 and CD8 were(3086 5 60)pg/mL and(35 54 8 82)%,respectively,which was significantly higher than that of patients with EDSSscore 25 and 3 6,the differences were statistically significant(P 005)The serum 25 (OH)D of patients wit
24、h EDSS score of 3 6 inthe observation group was(28 65 810)nmol/L,which was significantly lower than that of patients with EDSS score 25,while IL 6 andCD8 were(2502 5 34)pg/mL and(32 20 904)%,respectively,which was significantly higher than that of patients with EDSS score 2 5,the differences were st
25、atistically significant(P 0 05)There was no statistically significant difference in serum 25 (OH)D,IL 6,CD8 between patients with positive and negative aquaporin 4 antibody(AQP4 IgG)expression in the observation group(P 005)Serum 25(OH)D was negatively correlated with the number of spinal cord invol
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- 血清 25 OH IL 临床 特点 治疗 效果 关系 朱健清
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