日本普通人群中代谢综合征及植物甾酮的吸收异常发生率.pptx
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1、The 4th Shino-Japan Cardiovascular Forum on October 23-24,2008 in Beijing Frequency of Metabolic Syndrome and its Absorption Abnormality by Plant Sterols in General Population,JapanToshio Shimada,Yo Murakami,Nobuyuki Oyake,Hiroyuki Yoshitomi,Nobuhiro Kodani,Akira Matsumori*Division of Cardiovascular
2、 Medicine,Department of Internal Medicine,Shimane University Faculty of Medicine,Department of Cardiovascular Medicine,Kyoto University,Graduate School of Medicine*The 4th Shino-Japan Cardiovascular Forum on October 23-24,2008 in Beijing BackgroundHealth problems on aged people have been growing big
3、ger in Japan because with advancing age,a variety of diseases especially on vascular diseases,such as cardio-and cerebro-vascular diseases have been increasing.And therefore,early detection of vascular diseases is a very important issue for vascular prevention and reduction of mortality.The 4th Shin
4、o-Japan Cardiovascular Forum on October 23-24,2008 in Beijing Diagnostic Criteria for Metabolic Syndrome(8 Japanese Medical Associations Joint-Committee)Fat accumulation in the intra-abdominal cavityAbdominal Circumference at the WaistMale85cm,Female90cm(80cm recommended by me)(Visceral fat areaMale
5、 and Female 100 cm2)Hypertriglyceridemia 150 mg/dLLow HDL-cho 40 mg/dLSystolic Blood Pressure 130 mmHgDiastolic Blood Pressure 85 mmHgFasting Blood Sugar 110 mg/dL Lipoprotein abnormality High Blood Pressure High Blood Sugar At least,more than following 2 itemsand/orand/ormodified and translated int
6、o English by Toshio ShimadaMajor CriteriaMinor CriteriaThe 4th Shino-Japan Cardiovascular Forum on October 23-24,2008 in Beijing ObesityInsulin ResistanceDMDyslipidemiaHypertensionAtherosclerosisArteriosclerosisPathophysiology of Metabolic SyndrmeOver-eatingPoor ExerciseInheritanceThe 4th Shino-Japa
7、n Cardiovascular Forum on October 23-24,2008 in Beijing LDL ISynthesis of Cholesterol in the Liver and Absorption of Cholesterol in the Intestine-Two Important Supply Sources of Cholesterol in Vivo-BileFoodLiverVesselsCholesterolSmall IntestineBiliary8002000mg/dayDietary400500mg/dayThe 4th Shino-Jap
8、an Cardiovascular Forum on October 23-24,2008 in Beijing AimOur purpose is to investigate the frequency of metabolic syndrome(MS)and life style related diseases and also to examinewhether any difference in absorption of cholesterol from the digestive system is present in participants between with me
9、tabolic syndrome(MS)and non-MS randomly selected,using plant sterols in general population.The 4th Shino-Japan Cardiovascular Forum on October 23-24,2008 in Beijing Subjects and method In 2007,1980 participants for annual health check-up were subjected for this cohort study.Average age is 6610.8 yea
10、rs,and female is 1260(64%);male is 720(36%).All subjects underwent routine blood examinations,insulin,remnant like particle cholesterol(RemLC),hs-CRP,cystatin C,plasma brain natriuretic peptide(BNP)and N-terminal proBNP(NT-proBNP)measurements.Blood pressure,abdominal circumference,and electrocardiog
11、raphy were measured at the same time.Abdominal circumference was measured at the navel level in the supine position like CT for visceral fat.Evaluation of cholesterol absorption was done by plant sterols in each 30 participants chosen randomly from the participants.BNP and NT-proBNP were measured fo
12、r heart failure screening by immunoluminesence method.Plant sterols were measured by gas chromatography.The 4th Shino-Japan Cardiovascular Forum on October 23-24,2008 in Beijing In 1964 participants,218 participants(11%)were diagnosed as MS,using 80cm waist circumference in female and 85cm in male a
13、s major criterion.From each group,30 participants were randomly chosen to check plant sterol levels for the evaluation of absorption of cholesterol and lathosterol for the evaluation of cholesterol synthesis.Each sterol level was measured by gas chromatography.The Measurement of Serum Plant Sterols
14、to Evaluate Cholesterol Absorptionin Okuizumo Cohort,2007The 4th Shino-Japan Cardiovascular Forum on October 23-24,2008 in Beijing Abnormal and Normal Proportion of Clinical Paramerers in General Population,JapanOkuizumo Cohort 20070%10%20%30%40%50%60%70%80%90%100%SystBP(130mmHg)DiastBP(85mmHg)Gende
15、r(F/M)WaistCircum90-85WaistCircum80-85Metabo90-85Metabo80-85CKDnormalabnormalN=1972N=1972N=1972N=1972N=1972N=1972N=1972N=1980N=1964N=1964N=1964N=1964N=1980DM(HbA1c5.8%)(220mg/dL)TG(150mg/dL)LowHDL(40mg/dL)Obesity(BMI25)The 4th Shino-Japan Cardiovascular Forum on October 23-24,2008 in Beijing TruePos
16、itiveSensitivity0.000.100.200.300.400.500.600.700.800.901.00.00.10.20.30.40.50.60.70.80.901-SpecificityFalsePositiveUsingMSF90M85-Dx=0tobethepositivelevelAreaUnderCurve=0.93304ReceiverOperatingCharacteristicReceiverOperatingCharacteristicMetabolic Syndrome and its Influential Factors Analyzedby Mult
17、ivariate Logistic RegressionFemale Waist Circumference 90cm90cmInfluential ParametersBMIHbCystatin CInsulinRem LC TchoThe 4th Shino-Japan Cardiovascular Forum on October 23-24,2008 in Beijing TruePositiveSensitivity0.000.100.200.300.400.500.600.700.800.901.00.00.10.20.30.40.50.60.70.80.901-Specifici
18、tyFalsePositiveUsingAbd-CF80M85=0tobethepositivelevelAreaUnderCurve=0.89483ReceiverOperatingCharacteristicReceiverOperatingCharacteristicMetabolic Syndrome and its Influential Factors Analyzed by Multivariate Logistic Regression Female Waist Circumference 80cm80cmInfluential ParametersBMIHbCystatin
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- 关 键 词:
- 日本 普通 人群 代谢 综合征 植物 吸收 异常 发生率
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