硕士研究生英文文献汇报实例.ppt
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1、Ages and Stages Questionnaire at 3Years for Predicting IQ at 56 Years幼儿幼儿3岁时的发育岁时的发育情况(年龄和发育阶段问卷结果情况(年龄和发育阶段问卷结果)能预)能预测其测其5-6岁时的岁时的IQPEDIATRICS Volume 139,number 4,April 2017IF:6.476Yao xing,2017-11-07ContensBackgroundObjectivesMethodsResultsDiscussionStrengths and limitationsConclusionsImplications
2、AbbreviationsASQ:Ages&Stages Questionnaires(年龄与发育阶段问卷)(年龄与发育阶段问卷)CI:Confidence Interval(可信区间)(可信区间)EDEN:Etude des Determinants Pre-et Post-natals du Developpement de lEnfant(伊甸园队列)(伊甸园队列)IQR:Interquartile Range(四分位数间距)(四分位数间距)ROC:Receiver Operating Characteristic(受试者(受试者/接受者工作特接受者工作特征)征)SDQ:Strength
3、s and Difficulties Questionnaire(长处与困难问卷)(长处与困难问卷)WPPSI-III:Wechsler Preschool and Primary Scale of IntelligenceThird Edition(韦氏学龄前儿童智力量表,第(韦氏学龄前儿童智力量表,第3版)版)EDEN:Etude des Determinants Pre-et Post-natals du Developpement de lEnfantThe EDEN motherchild cohort study aims to examine prenatal and postn
4、atal determinants of child development,growth,and health.Participants were recruited between 2003 and 2006 among pregnant women followed in Poitiers and Nancy university maternities.Exclusion criteria were multiple pregnancies(多胎妊娠),a known history of diabetes,nonFrench speakers or readers,or plans
5、to move out of the study region in the next 3 years.BACKGROUND1.The identification of young children at risk for later suboptimal development is key to the design and implementation of early preventive or interventional strategies.2.Parental report instruments are designed to be used in primary care
6、 for firstline clinical screening of infant and preschool child development.3.The Ages&Stages Questionnaires(ASQ)are the most commonly used questionnaires to identify young children at risk for developmental delay.4.Previous evidence from a population of children born preterm showed that the 36-mont
7、h ASQ predicted school difficulties at age 5.5.There is a gap in knowledge about the predictive value of early ASQ scores for later cognitive functioning,such as IQ,in the general pediatric population.OBJECTIVES1.To investigate the predictive value of the 36-month ASQ score for IQ at age 5 to 6 year
8、s in a large population-based cohort study.2.To search for other child,maternal,and family-related factors associated with low IQ once the 36-month ASQ score is taken into account and to determine whether such factors could interact in the relationship between the 36-month ASQ score and later IQ.MET
9、HODS1.Measures of child development2.1 36-Month ASQ Score(French Second Edition)Parents answer 6 questions in each of 5 domains of development:communication(沟通),gross motor(粗大动作),fine motor(精细动作),problem-solving skills(解决问题能力),and adaptive skills(适应能力).US norms are available for each domain,and any
10、domain screened 2 SDs below the mean is considered a positive screening.This study used the sum or the 5 domain scores,producing a score between 0 and 300.1.Measures of child development2.2 IQ With the Wechsler Preschool and Primary Scale of IntelligenceThird Edition at Age 5 to 6 YearsWhen the chil
11、d was 5 to 6 years old,cognitive assessment was performed by trained psychologists.The WPPSI-III includes 7 subtests used to compute a verbal IQ,a performance IQ,and a full-scale IQ.IQ was considered low if it was 85.When the children were 3 years old,mothers filled out a questionnaire reporting soc
12、iodemographic status for the family and specific data on current maternal health,together with the ASQ.When the children were 5 to 6 years old,a cognitive assessment was conducted by trained psychologists.1.Measures of child development2.Factors included in the analysis1.Childs characteristics:gende
13、r;whether the child was a firstborn child;behavioral problems at age 3,rated via the Strengths and Difficulties Questionnaire(SDQ),and whether the child had started preschool at age 3.2.Maternal characteristics:maternal educational level,occupation,and depressive symptoms assessed with the Center fo
14、r Epidemiologic StudiesDepression scale.3.Family characteristics:parents occupation and financial difficulties reported by the parents when the child was 3.3.Statistical analysis1.Children included in the current analysis were first compared with the other children in the EDEN cohort who were not in
15、cluded.2.Results for the 36-month ASQ score and the 5-to 6-year WPPSI-III evaluation were described as means SDs and median with interquartile ranges(IQRs).3.The receiver operating characteristic(ROC)curve linking low IQ(85)and ASQ score was used to determine the optimal cutoff value for the ASQ sco
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