Brainppt课件.pptx
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1、LOGOGenetic impact on cognition and brain function in newly diagnosed Parkinsons disease:ICICLE-PD study Lab of Neuroscience of West China Hospital Zhao Xiaoyan 2014.09.271.Contents 1Spatial Rotations Task2Memory Encoding Task3 Functional MRI4Tower of London Task2.Tower of London Taskv Prefrontal ex
2、ecutive function;three levels of difficulty;No feedback;The dependent variables were the latency of response3.Spatial Rotations TaskSpatial impairmentsThis task to probe posterior cortical function(后皮质)4.Memory Encoding Task5.Memory Encoding Task Memory deficits in PD are most related to encodingLin
3、ked to hippocampal function 5 15 s of six images for 4 s each 30 different images in the scanner18 of them appeared once,12 appeared twice 6.AbbreviationsDLPFC=dorsolateral prefrontal cortex 背外侧前额叶皮层ICICLE-PD=Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation Parkinsons Diseas
4、e 在PD的纵向队列研究中认知功能障碍的发生率LEDD=levodopa equivalent daily doseMMSE=Mini-Mental State Examination 简易精神状态测试MOCA=Montreal Cognitive Assessment 蒙特利尔认知评估量表NART=National Adult Reading TestMDS-UPDRS=Unified Parkinsons Disease Rating Scale7.Inclusion and exclusion Exclusion1.Parkinsonism diagnosed before the on
5、set of the incidence study2.insufficient working knowledge of English to perform the neuropsychological assessment3.dementia at presentation 4.criteria for dementia or Movement Disorder 5.history or examination suggestive of dementia with Lewy bodies,MSA,PSP,repeated strokes or stepwise progression
6、of symptoms indicative of vascular parkinsonismInclusionincident Parkinsons disease UKPDS:the United Kingdom Parkinsons Disease Society Brain Bank diagnostic criteria8.PreparationvParticipants undertook clinical and neuropsychological assessments:vthe Unified Parkinsons Disease,MDS-UPDRS,MMSE,NART e
7、stimate of premorbid IQ;verbal fluency for words and semantic fluency,LEDD value vPatients were assessed ON their usual dopaminergic medication.vDNA was extracted from peripheral bloodvGenotyping for rs4680(COMT Val 158 Met),rs9468(MAPT H1 versus H2 haplotype)rs429358 plus rs7412(APOE genotype 14)9.
8、ResultsFig 1Activity during planning minus control condition on Tower of London TaskActivity during rotations minus baseline on Spatial Rotations Task Activity during encoding minus baseline on the Encoding Memory Task Figures show areas of signal change above a threshold of P=0.05 after FDR correct
9、ion for the whole brain volume Basic condition10.Results1.Gender,age,MOCA and MMSE scores were matched between groups and sites11.2.For years of education,fewer years at Site 2,and a main effect of disease group:controls spent longer in formal education 3.category and letter fluency scores,there wer
10、e differences between groups(higher score in controls)and sites(higher scores at Site 1)4.an interaction between disease and site for category fluency with relatively higher scores in controls at Site 1.Results12.Behavioral performance by groups Results Tower of LondonFig 2 (A)Latency of response To
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