胶质瘤基因表达与影像学之间的联系——文献回顾及展望ppt课件.pptx
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1、胶质瘤基因表达与影像学之间的联系胶质瘤基因表达与影像学之间的联系文献文献回顾及展望回顾及展望北京市神经外科研究所STAR MARKERS AND COMMON IMAGINGStar markers:-MGMT -IDH1 -EGFR -1p/19q -TP53 -Ki-67 -PTEN -MIB-1 -Others -TypesCommon imaging:-T1/T2 -T1+-FLAIR -CBV -DTI/DWI -DCE-MR -MRS -PET -SPECTIDH11p/19qEGFRP53MGMTT1/T2 1.Albert Lai,et al 2011 2.Carrillo,J
2、.A.,et al 2012 3.Metellus,Philippe,et al 2010 1.Metellus,Philippe,et al 2010 2.Megyesi JF,et al 2004 3.Kim JW,et al 2011 1.Diehn,Maximilian,et al 2008 2.Shazeeb MS,et al 2011 3.Mu,Ketao,et al 2015 1.Wang,Y Y,et al 2014 2.Wang,Y Y,et al 2015 1.Carrillo JA,et al 2012 2.Sunwoo L,et al 2013 3.Ahn,Sung S
3、oo,et al 2014 FLAIR 1.Ellingson BM,et al 2013 2.Metellus,Philippe,et al 2010 3.Pope,W.B,et al 2012 1.Metellus,Philippe,et al 20101.Ellingson BM,et al 2013 1.Liu C,et al 2012 1.Ellingson BM,et al 2013T1+1.Albert Lai,et al 2011 2.Ellingson BM,et al 2013 3.Metellus,Philippe,et al 2010 1.Metellus,Philip
4、pe,et al 20101.Ellingson BM,et al 2013 1.Sunwoo L,et al 2013 2.Ahn,Sung Soo,et al 2014 3.Ellingson BM,et al 2013DTI 1.Tan,W L,et al 2014 1.Ahn,Sung Soo,et al 2014DWI(ADC)1.Sunwoo L,et al 2013 CBVMRS 1.Pope,W.B,et al 2012DCE-MRI 1.Ahn,Sung Soo,et al 2014PETSPECTSTAR MARKERS AND COMMON IMAGINGPTENMIB-
5、1Ki-67OthersTypesT1/T2 1.Jamshidi N,et al 2012 2.Gevaert,Olivier,et al 2014 3.Fan,Xing,et al 2015 1.Naeini KM,et al 2013FLAIR 1.Liu C,et al 2012 1.Gevaert,Olivier,et al 2014 T1+DTI 1.Bell,C.et al 2014 DWI(ADC)1.Zikou,A.K.,et al 2012CBV 1.Zikou,A.K.,et al 2012 MRS 1.Yu TG,et al 2015DCE-MRI PETSPECTST
6、AR MARKERS AND COMMON IMAGINGMGMTMGMT1 1、水肿很少出现甚至不会出现在甲基化的肿瘤周围、水肿很少出现甚至不会出现在甲基化的肿瘤周围4。2 2、MGMTMGMT状态需要纹理特征分析才能够建立与状态需要纹理特征分析才能够建立与MRIMRI特征的联系特征的联系8、9。3 3、MGMTMGMT与与ADCADC呈正相关,呈正相关,ADCADC与与PFSPFS呈正相关呈正相关10。4 4、M MG GM MT T甲甲基基化化的的肿肿瘤瘤容容易易出出现现在在左左侧侧颞颞叶叶,而而M MG GM MT T非非甲甲基基化化的的肿瘤更倾向于长在右侧半球肿瘤更倾向于长在右侧半球
7、3 。5 5、MGMTMGMT非甲基化和非甲基化和EGFREGFR扩增的肿瘤容易生长在右侧岛叶,丘脑,扩增的肿瘤容易生长在右侧岛叶,丘脑,颞叶并向侧脑室后部室管膜下区延伸颞叶并向侧脑室后部室管膜下区延伸10。6 6、非非甲甲基基化化的的M MG GM MT T肿肿瘤瘤在在T T1 1增增强强和和T T2 2/F FL LA AI IR R像像上上比比M MG GM MT T甲甲基基化化的肿瘤强化面积大的肿瘤强化面积大3。PROBABILISTIC RADIOGRAPHIC ATLAS OF GLIOBLASTOMA PHENOTYPESB.M.Ellingson.et al,AJNR,2013
8、MGMT promoter methylated tumors occur more frequently in the left temporal lobet-valuePrediction of methylguanine methyltransferase promoter methylation in glioblastoma using dynamic contrast-enhanced magnetic resonance and diffusion tensor imagingSungSoo Ahn.et al,J Neurosurg,2014DCE-MRI permeabili
9、ty parameters:Ktrans may serve as a potential imaging biomarker to predict MGMT methylation status in glioblastoma.CORRELATION OF APPARENT DIFFUSION COEFFICIENT VALUES MEASURED BY DIFFUSION MRI AND MGMT PROMOTER METHYLATION SEMIQUANTITATIVELY ANALYZED WITH MS-MLPA IN PATIENTS WITH GLIOBLASTOMA MULTI
10、FORME methylated MGMTUn-methylated MGMTT1WADCThe mean ADC revealed a positive relationship with MGMT promoter methylation ratioLeonard Sunwoo et al,Journal MRI,2012IDH1IDH11 1、IDH1IDH1突变的肿瘤好发于额叶而且肿瘤细胞临近脑室下区突变的肿瘤好发于额叶而且肿瘤细胞临近脑室下区3,3。2 2、用标准的、用标准的MRIMRI特征就可预测特征就可预测IDH1IDH1的表达状态的表达状态4。3 3、在在D DT TI I相相
11、中中,利利用用部部分分异异向向分分数数和和A AD DC C可可以以在在星星形形细细胞胞胶胶质质瘤瘤中监测中监测IDH1 R132HIDH1 R132H的突变情况的突变情况5。4 4、随随着着年年龄龄上上升升,I ID DH H1 1突突变变减减少少,肿肿瘤瘤更更容容易易长长在在岛岛叶叶并并且且1p/19q1p/19q均表现为阴性均表现为阴性6。RELATIONSHIP BETWEEN TUMOR ENHANCEMENT,EDEMA,IDH1 MUTATIONAL STATUS,MGMTPROMOTER METHYLATION,AND SURVIVAL IN GLIOBLASTOMAAll I
12、DH1 mutant tumors were non-contrast enhancing tumor positive,and most were located in the frontal lobe.J.A.Carrillo et al,AJNR,2012DETECTING ISOCITRATE DEHYDROGENASE GENE MUTATIONS IN OLIGODENDROGLIAL TUMORS USING DIFFUSION TENSOR IMAGING METRICS AND THEIR CORRELATIONS WITH PROLIFERATION AND MICROVA
13、SCULAR DENSITYFAADCIDH1(-)IDH1(+)Ji Xiong et al,Journal MRI,2015This study demonstrated that the MaxFA and MinADC are useful DTI parameters for differentiating Oligodendroglial Tumors with and without IDH mutations.CAN DIFFUSION TENSOR IMAGING NONINVASIVELY DETECT IDH1 GENE MUTATIONS IN ASTROGLIOMAS
14、?A RETROSPECTIVE STUDY OF 112 CASESThis study demonstrates that DTI metrics have potential ability to distinguish astrogliomas with IDH1 mutation from those without mutation.FAADCIDH1(-)IDH1(+)W.L.Tan et al,AJNR,2014NON-INVASIVE DETECTION OF 2-HYDROXYGLUTARATE AND OTHER METABOLITES IN IDH1 MUTANT GL
15、IOMA PATIENTS USING MAGNETIC RESONANCE SPECTROSCOPYWater-suppressed proton(1H)MRS provides a non-invasive measure of 2-HG in gliomas,and may serve as a potential biomarker for patients with IDH1 mutant brain tumors.IDH1mutantWild-typeWhitney et al,J Neurooncol,2013EGFREGFR1 1、E EG GF FR R扩扩增增和和E EG
16、GF FR R-突突变变的的G GB BM M普普遍遍出出现现在在左左颞颞极极延延伸伸到到左左岛岛叶区域叶区域3。2 2、E EG GF FR R过过表表达达的的G GB BM M对对比比增增强强体体积积更更大大10 但但与与P PT TE EN N,1 10 0号号染染色色体单倍体或多倍体的体单倍体或多倍体的GBMGBM相比并没有明显的差异相比并没有明显的差异3。3 3、E EG GF FR R通通过过表表达达E EG GF FR R-促促进进胶胶质质母母细细胞胞瘤瘤微微血血管管形形成成。目目前前的的研研究究只只停停留留在在通通过过顺顺磁磁性性氧氧化化铁铁合合成成的的E EG GF FR R
17、共共轭轭体体检检测测E EG GF FR R受受体体水平和通过水平和通过diTyr-GdDTPAdiTyr-GdDTPA观察观察EGFREGFR的表达水平的表达水平11、12。PROBABILISTIC RADIOGRAPHIC ATLAS OF GLIOBLASTOMA PHENOTYPESEllingson et al,AJNR,2013EGFR amplified and EGFR variant 3-expressing tumors occurred most frequently in the left temporal lobe.TARGETED SIGNAL AMPLIFYIN
18、G ENZYMES ENHANCE MAGNETIC RESONANCE IMAGING OF EGFR EXPRESSION IN AN ORTHOTOPIC MODEL OF HUMAN GLIOMA3T MR can reveale EGFR expression through diTyr-GdDTPAMohammed et al,Cancer Res,20121P/19Q1P/19Q1p/19q1p/19q缺失的间变性少突胶质细胞瘤在缺失的间变性少突胶质细胞瘤在T1/T2T1/T2上表现为边缘上表现为边缘不规则,不均匀强化,呈浸润状态的异缘信号不规则,不均匀强化,呈浸润状态的异缘信号
19、7,7。LOWER APPARENT DIFFUSION COEFFICIENTS INDICATE DISTINCT PROGNOSIS IN LOW-GRADE AND HIGH-GRADE GLIOMAA threshold mean ADC value could predict the 1p/19q codeletion and identify low-risk LGGs.J W Kim et al,J Neurol Neurosurg Psychiatry,2011PREDICTION OF OLIGODENDROGLIAL HISTOLOGY AND LOH 1P/19Q US
20、ING DYNAMIC 18FFET-PET IMAGING IN INTRACRANIAL WHO GRADE II AND IIIGLIOMASLOH 1p/19qNon-LOH 1p/19qNathalie L et al,Neuro-oncology,2012RELATIONSHIP BETWEEN RADIOLOGICAL CHARACTERISTICS AND COMBINED 1P AND 19Q DELETION IN WORLD HEALTH ORGANIZATION GRADE III OLIGODENDROGLIAL TUMOURSJ W Kim et al,J Neur
21、ol Neurosurg Psychiatry,2011Significant relationships between the 1p19q codeletion and magnetic resonance image characteristics in oligodendroglial tumours such as frontal location,an indistinct tumour border.1p19qcodeletion Intact 1p19qKI-67KI-67用用SeedlinkSeedlink方法可以成功找到方法可以成功找到Ki-67Ki-67的热点的热点16。
22、COMPARISON OF MULTIPLE PARAMETERS OBTAINED ON 3T PULSED ARTERIAL SPIN-LABELING,DIFFUSION TENSOR IMAGING,AND MRS AND THE KI-67 LABELING INDEX IN EVALUATING GLIOMA GRADINGSignificant correlations were observed between the Ki-67 index and the mean,maximum,and minimum ADC,Cho/Cr,and lactate/Cr ratios.II
23、IVH.Fudaba et al,AJNR,2014CORRELATION OF DIFFUSION TENSOR,DYNAMIC SUSCEPTIBILITY CONTRAST MRI AND 99MTC-TETROFOSMIN BRAIN SPECT WITH TUMOUR GRADE AND KI-67 IMMUNOHISTOCHEMISTRY IN GLIOMAThis study showed that the findings on perfusion MRI and brain SPECT with99mTc-Tetrofosmin were most closely corre
24、lated with Ki-67 index.Ki-672%Ki-6730%George A et al,Clinical Neurology and Neurosurgery,2014FRACTIONAL ANISOTROPY AND TUMOR CELL DENSITY OF THE TUMOR CORE SHOW POSITIVE CORRELATION IN DIFFUSION TENSOR MAGNETIC RESONANCE IMAGING OF MALIGNANT BRAIN TUMORSDTI(FA and MD)show positive correlation with K
25、i-67 labeling indexManabu Kinoshita et al,NeuroImage,2008DIFFUSION TENSOR AND DYNAMIC SUSCEPTIBILITY CONTRAST MRI IN GLIOBLASTOMAA significant correlation was observed between Ki-67 index and ADC,FA ratio,rCBV and rMTT.Anastasia K et al,Clinical Neurology and Neurosurgery,2012AMIDE PROTON TRANSFER I
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