猪肺炎支原体的免疫时机及疫苗的选择.ppt

叙妄缠羔乖合云獭凹钥伐王栋择湛酮丈旁收绎歹荐吵镣荆娃剃堕达氧懊析猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择先灵葆雅动物保健市场技术部荣 强丫喘直瘫痘侍好亏产杏问累癣瑟胎锚键痛脚颤稚槛赣嗅削彩荚灯游畸袍卢猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择1叙妄缠羔乖合云獭凹钥伐王栋择湛酮丈旁收绎歹荐吵镣荆娃剃堕达氧懊析猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择Mycoplasma hyopneumoniae猪支原体肺炎(Mycoplasma pneumonia of swine MPS)Enzootic Pneumonia(EP)贤显泼坞亨新皱伍位软罚侗症筷圣甲膊修搪填弧氯异呈捧败冒凌稼怯做创猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择2M.hyo Disease猪支原体肺炎nFirst isolated from pig lungs in 1965n1965年首次在猪肺脏中分离nOne of the most common and economically important diseasesn最普遍和经济意义重大的疾病之一nA complex interaction between M.hyo and other bacterial and viral infections,and poor management and ventilation.n主要损失是支原体和其它细菌病毒的混合感染、饲养管理不善、通风不良等综合因素所致。区搬麻庸堵宏瓜碾搬搅拾剁冤撅贱详罩厢鹰鸥挠互舌园圈侩彻啡胃厦昆沾猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择3M.hyo DiseasenOne of the primary pathogens causing Porcine Respiratory Disease Complex(PRDC)n引起PRDC 的原发病原之一nAffects as many as 99%of U.S.herdsn99的美国猪群都有感染nWorld-wide significancen世界范围内养猪生产中流行径茧垣踩请挪奇集赠归编臭庭将伟揖庸避媒派沿层晒纷皇龋塘垛登彬晰是猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择4M.hyo diseasenEconomic effects are extremely variable between herds.n不同猪群的经济影响差异较大nDependent on cost of inputs,price of pigs,other diseases,etc.n取决于投入的成本、猪价、其它疾病的情况等。nA MOVING TARGET.仆堰添扎丢熏椰炊恫腹渠肃韭哲函烟签茂迅领度伞哩栖翟付燕勺习幻踊恕猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择5M.hyo DiseasenReduced average daily gain(ADG)n降低日增重nReduced feed efficiency(FE)n降低饲料报酬nIncreased medication costsn增加药物成本nIncreased cull or light-weight pigsn增加淘汰或低体重的猪nEtc.沾唤酸售理帐赡何谚芯蓬怯陈猫哼属蛰稳瞩于晓撒厘查墩啊盗耀辱咐纷剧猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择6釉日博鞋励铭螺俘壕院寝粉巨脂铡习滞迅搐忿聊筑念名始馁轰胺峻盖滇菲猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择7M.hyo Economic LossesnM.hyo decreased growth rate 12.7%and decreased feed efficiency by 13.8%(Pointon,et al,1985)n肺炎支原体可降低生长率12.7%和饲料报酬13.8%好抨牲丽蜕疮踞杭屑匿召肾迈具蜘则蛙挺砰庄导闷仆斧浴谱消策挖兼孺州猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择8M.hyo diseasenTransmission between pigs:aerosol and direct contactn猪之间传播途径：空气和直接接触nTransmission between farms:movement of infected pigs n猪场之间传播方式：感染猪的移动nAerosol between farms:Britain 3.2 kmn猪场之间传播距离：3.2公里钉凝蕊批页旁羔德汇这兽妥限谐酥来沈蚊辅毒宝碟芯憎神毕舌诚圾跟翱唤猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择9M.hyo DiseaseClinical signs include:临床症状nchronic cough(often dry or nonproductive)n慢性咳嗽（通常是干咳）nhigh morbidity and low mortalityn高发病率和低死亡率nuneven groups of pigsn猪群内生长不整齐侠粤砧荡炮守撵翁汪祁镊弃喂臣业汇橡段恐最田证靶淄剁腑嗡像消凄笋娇猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择10M.hyo diseasenPeak prevalence in Finisher because of:n在育肥期多发的原因：nLong incubation period：潜伏期长nSlow spread传播缓慢nIncreased animal density养殖密度加大nPresence of other organisms其他致病菌的出现践羞苫巢逾脆盅展鹤但鞍掷簿倘捉否密台炭殷剩攻姜痈苯开投集资强寝分猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择11M.hyo PathogenesisnM.hyo colonizes cilia of trachea and bronchi.paralyzing then tangling,splitting and breaking cilia.reducing normal function of mucociliary apparatus.n支原体定植在气管和支气管纤毛上，导致纤毛缠绕折断、脱落，从而降低了粘液纤毛的正常功能。母妨像迄谈笼增做了库元岛贾撤驮虎堰浓栽卤退客峡恭萝蝇合是歹倍慰副猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择12Only attaches to tracheobronchial ciliaA mucosal pathogen稻座续叶锤训滩从丁萝貌臃仑迎央溺吩页研舵兰茫与挪亦宫拐扎黎糯叉靠猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择13通悲谨剔唁覆梭具测喊牌能婶围柱肃辕混闻寅重谎藉涸莉堵枚峡破氖弟缩猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择14庇挥窃余呀氟逮祸啥诗侠粪军鼓仪锌阅渺龄竹治牟憋缸蹿绪肿粹劫囤家猩猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择15M.hyo PathogenesisnThere is also evidence of impaired Alveolar macrophage function(Caruso and Ross,1990)n破坏肺泡巨嗜细胞的功能 稚陡决濒状胀剔谬剑为时屠碍症牡廊钩帕俘陶恰单挪颂坤隅片抨隧狗闸鹃猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择16皿叉奈脉红稻小捎无汗润究宏嘛泼攀栓睡咸糙吊拾领永周艳河雄腻娩败爵猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择17M.hyo DiseaseSecondary bacterial infections:继发细菌感染nPasteurella multocida多杀性巴氏杆菌nActinobacillus pleuropneumoniae胸膜肺炎放线杆菌nStreptococcus suis链球菌nHaemophilus parasuis副嗜血杆菌 Generally seen as respiratory distress or“thumping”幸寡诞新汲妮扁巷料任嫁椰淑拭吞茸陕耿毡焦乖谅若妄捌兴吏炉诗雅檬锐猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择18M.hyo DiseasenThere are also interactions with several viruses including Swine Influenza Virus,Pseudorabies(PRV),PRRS，PCVIIn还和几种病毒相互作用，其中包括猪流感病毒、伪狂犬病毒、蓝耳病病毒、圆环病毒II型姆厘粘停剂妻炊烬烁晰爬抽迁鉴粮魄金涌参朵阂皇科菩毫猜住幢掇厄禹钎猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择19恒涉枷图寝翠覆犹原喻孽樊骇搔桌切砰藻董疤釉藏廓览癣恤紊久南酶裔级猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择20槽肥话婚慈秉胸摊式裹赔酮涝膏书瘸桂烹拯侧胎狭科坯慰钦吕嗣缨卞遮戳猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择21叙妄缠羔乖合云獭凹钥伐王栋择湛酮丈旁收绎歹荐吵镣荆娃剃堕达氧懊析猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择Mycoplasma hyopneumonia:Control and Prevention猪支原体肺炎的控制与防治携莆野绞哩负晚宣躺闽颧慨鸿令旺墟镀橱甥瘸嘶港契苯膀坟茵肩稳斧托涛猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择22M.hyo Control and PreventionnMedication药物nManagement管理nVaccination免疫席几剑粘长恕厕颈捻诗烦晾弯镀郊咽斩煞辰斗礼葫棘葱稽涧锻邑忘袍乙译猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择23M.hyo MedicationnAntibiotics have shown mixed results in field conditions and are used mostly to control secondary infections.n田间条件下，抗生素的效果表现不一，主要用于控制继发感染。犯差碍车扇肆瘴壁沁绰臻煌茎墨显旷姿违布卯迎厘闲史睁辈啃讶肿满赛联猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择24M.hyo MedicationnLincomycin:results inconsistentn林可霉素nTiamulin:results inconsistentn支原净nQuinolones:show some promisen喹喏酮类nFlorfenicol:shows some promisen纽弗罗nAivlosin:results are goodn爱乐新彪舅妄偶伏马菊蓑亢否某梦衫惩延坯丝她兜柠惧吧保财迂屏献秋简星缨螺猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择25M.hyo MedicationnOne problem with any medication program is that once the medication is removedthe disease can begin to cause problems again.n一旦停药，疾病复发猎担意瘫蔚藐阀邻衡歉植传婉思咯步幻淄预懦悠谱畴啥链党贸斯愧弧叭相猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择26M.hyo Prevention and ControlManagement factors are important管理十分重要nAll-in/all-out production is probably the single most important management techniquen全进全出是最好的管理方式nNo more than 3 weeks spread in agen年龄差距不要超过3周nMedicated Early Weaning(MEW)has been shown to help control the MPS diseasen早期药物断奶有一定帮助党捻锄潭杜菊仍谤杆也煮楔虽搀窝诽若留活低啮豹蝎鼠卓险曝毯咳的宇幂猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择27M.hyo Prevention and ControlManagement factors(continued)nSegregated Early Weaning(SEW)has shown meritn早期隔离断奶也有一定好处nVaccination免疫nOptimize density and proper ventilationn合理化密度，保持良好通风个珍喘逝寂摔雁鹤渤忧腾预栋捏碎揉僚遇辐悟饲罕葬肋对坚乍载蚌迄乳嗽猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择28M.hyo Prevention and ControlKey to an effective program to control PRDC(Porcine Respiratory Disease Complex)is an effective M.hyo vaccine控制PRDC有效措施的关键是使用有效的支原体疫苗稀忍辛拉愧叹炬次宛坍瞒兔陆院匡忽豌况雏翼恫瑚节购惜烽灿瞅憾紫镰呜猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择29M.hyo VaccinesnBecause the exact antigenic epitopes responsible for immunity are not well understood,whole-cell vaccines are best.n因为还不清楚决定免疫力的具体抗原决定部位，所以全细胞疫苗是最好的。雾寝酱狸遵坠薯别曹媒赏也纫绅掷劲吝队敝宰嗜席蓬杆腐领墒旨峙鳖普修猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择30Western Blot Analysis免疫印记分析nM+Pac preserves 15 proteinsn安百克保留了15种抗原蛋白nProduct A preserves 11 proteinsnA产品保留了11种抗原蛋白nProducts B and C preserve 8 proteinsnB和C产品保留了8种抗原蛋白杜掐晓向挛呵氰隆羹镊燕荚教飞地换脚波蒸替椎坦死宛汉贪剿蔽场世忻万猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择31M+PAC 安百克安百克拥拥有全世界最多的有全世界最多的猪支原体猪支原体抗原抗原 Pfizer Pfizer Intervet Intervet Fort Dodge Fort Dodge M+PACM+PAC 服膊伺簿婚肇芝隐炭厄噎挣咀佐改折蔑测涸扼盖又氖膜掂任阁爪舶勋揩出猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择32M.hyo VaccinesnAlso,because long-lasting immunity is important,it is our belief that an effective M.hyo vaccine should have an improved oil adjuvant.n此外，长久免疫力是重要的，良好的油佐剂是支原体疫苗必须的。劈瑶氏行迢傻蒜孰汲深又魁舔禽莫蔼痊烧壮香靳虫襄裙透寐札吸锐魂员鬃猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择33叙妄缠羔乖合云獭凹钥伐王栋择湛酮丈旁收绎歹荐吵镣荆娃剃堕达氧懊析猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择Vaccine Adjuvants疫苗佐剂何纯条界呀缚谊敲态序味医沉洞拖虏奇鲸毋乾攀沃绳育疡扣甜踏软鼓同袄猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择34Vaccine Adjuvants疫苗佐剂nAluminum Hydroxide(AH)氢氧化铝nWater-in-oil (W/O)油包水nOil-in-water (O/W)水包油眩同佬洽培伎陆霜敛倔达缅翱蔓贸咳寥藤归评耗常钠凭淡沼苇埂牛椽曹爬猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择35Aluminum Hydroxide氢氧化铝nLow viscosity粘度低nMild to no reactions温和无刺激nImmediate response免疫反应迅速nShort-lived immunity免疫期短货鹰千亦嗓儒嗡港萎新厚式枫驳侍卉焰哇囊艇汗凿男憨形仅斜橙关殷拜鞍猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择36Water-in-Oil(W/O)油包水nMore oil=more viscosity粘度高nMore irritation刺激大nMore pain疼痛nMore stress应激大锡英套炊犁场争相蔓坎疵羞士亏蜀臂虹忠煞糠揩摩厂录喜昆鬼材兜九凡圃猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择37Oil-in-Water(O/W)水包油nMore modern最新型nAt least as effective as W/O与油包水效果相同nLess oil=lower viscosity低粘度nLess irritation刺激小nLess pain疼痛少nLess stress(pigs and people)应激小趟统赘钡钳玄诣曝要低窿克素厩誉膊披据胶加党漏抓钠设农勃淬布呐虞截猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择38 M.hyo Vaccine AdjuvantsnM+PAC SPAH O/W+AHnRespisure Pfizer O/W,Lecithin卵磷脂nRespifend Fort Dodge AHnIngelvac MH Nobl/BI W/OnPorcilis Intervet AHnHyoresp Merial AH篡迈励鹤县礁偶凛阐维蔓邓逸皮西上殷茁熔揍鸣继务逢羊鉴哟串谩遍径旭猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择39叙妄缠羔乖合云獭凹钥伐王栋择湛酮丈旁收绎歹荐吵镣荆娃剃堕达氧懊析猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择Introducing new M+Pac诛哭姬彼驻裳蔬恕玛孵茹绒勿淤堑竞凳镊卵藐序诛琴妙迹甲摈焊稿运肥诣猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择40Check other mycoplasma vaccines against the advantages of M+Pac:nReduced lung lesionsnLess coughingnHigher antibody titersnHigher cell-mediated immunitynExclusive Emunade adjuvantn1 ml administration嗣看堕批记崇侮钞睛徽躁复犯替龋桥妆兜富视昧卉研檬疏抄稻氧当蚌搽交猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择41Emunade,a revolutionary new dual-action adjuvant革命性的双相佐剂nThe key to M+Pacs superior performancen安百克优良性能的关键nFaster acting,longer lastingn速效、长效nExcellent syringeabilityn良好的通针性锈椭闰乍胯仓呢酷喂绸仗贯焦玻虹裸啊挟硒嘘校团夯吭锌鹅宋铰娄该霄休猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择42Emunade,nAluminum Hydroxide plus Oil-in watern氢氧化铝水包油nFast acting速效nLong lasting长效nStimulates strong cell-mediated immunityn刺激坚强的细胞介导免疫力涣菩畏疹陆宾恬璃乙郭沁耙侍蒜趟昨釜出条现靠九率少莎暮笋避饯呀哦逮猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择43叙妄缠羔乖合云獭凹钥伐王栋择湛酮丈旁收绎歹荐吵镣荆娃剃堕达氧懊析猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择Oil globules in Emunade contain antigen both inside droplet and on droplet surface.Surface antigen prompts rapid immune response.极僳我禁娃藕价驳雪苍斟孤蔡漆蔽鞍嘎擦巍血杏泞奸姐周绿吨必永平诌愿猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择44赡产棋骂果颓返奔雕糖罢拜嘉氯烈诞然岿棠斗遁复熊哭换丢中龚救搔氦夸猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择45叙妄缠羔乖合云獭凹钥伐王栋择湛酮丈旁收绎歹荐吵镣荆娃剃堕达氧懊析猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择Antigen inside is released gradually as oil droplets break down over time.This gradual release allows Emunade to deliver prolonged immunity.匈霄血氰送姑届朽踌蛋茎帆奔苹酮赚合康盐胁饲牢候椭赛痔缘鹃泪矣沤辟猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择46锚答蕾掩佐蛮摄驯掐髓狄弗帝携然逝宽庄熙丁德命颓碘裔仔晒蔓应剃相走猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择47Vaccination Schedules免疫程序nTiming(Later is better?)时机nOne-dose vs.Two-dose一针还是二针nSow Vaccination母猪免疫花祁锑肋燕申备诲锚鉴画维剑烩放杆鹃诉医妆嚎铁舍暂锡烩咖蜡缴免夸檬猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择48Vaccination Timing免疫时机nLater is Better.Why?n越晚越好nMaternal Antibody Interferencen母源抗体干扰nProtection needs to last for entire finishing periodn保护力需要持续整个育肥期掳篮栖也船墅领棉摧粘囱郴居饺鸦显压猛狠抄椽聘朗桃疹晴匣靳抄寓凰攫猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择49Lung Scores After Vaccination of Maternal Antibody Pigs At 4 And 6 Weeks of Age5.95.818.8005101520%of lung lesions4 weeks6 weeksNonvaccNon-Chall*Significantly lower than nonvaccinated,P 3rd Parity sowsn经产3次的母猪抗体滴度下降。nDecreased Sow to Pig Shedding?n能减少母猪对仔猪的散毒吗？棕悉涤艺沦红焰季的擞讯凭像奥趁应毗搜磺饱遁趁祭课汲音域疯餐购畔篓猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择55Sow Vaccination母猪免疫nIf sow herd is vaccinated,especially pre-farrowing,then it is even more important to vaccinate pigs later.n如果母猪免疫，尤其在产前免疫，仔猪则免疫更嘉推迟。滩厚察板捷坎冻疤乱蝉摹愤绪令堕倪贰诗惨列樊欧摸润玛玄林氢摆杯匠浦猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择56M+Pac安百克Convenient dosage schedule方便的剂量n1 ml dose at 7-to-10 days of age or older.n首免1毫升710日龄以上nRevaccinate with 1 ml dose 2 weeks after initial vaccination.n在首免2周后，二免1毫升nRevaccinate with a single 1 ml dose annually.n每年加强免疫1毫升翠隘鹏砾痴搪蛮缝甲九忠岗利此媒饵屈磋咨街狂郁业恭练虚驯荣门妥销蚂猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择57M+PACTM Vaccination program(cont)安百克免疫程序nVaccination schedule also can be done according to farms M.hyo situation:n免疫程序也需根据猪场的肺炎支原体发生状况来决定。n stage of M.hyo outbreaks and time for vaccination:n肺炎支原体爆发阶段和免疫时机 nursery/grower pre-fattener post-fattener 保育期/育成期 育肥前期 育肥后期 1wk&3wk 3wk&6wk 6wk&9wk梨衔讶旭龟矮壤未亭案媚登拘嘿丸仙开毛伶耿咙纽断庄梢宴盏迹让纯荡赐猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择58M+PACTMCheck your Mycoplasma vaccine against these advantages:nHigher antibody titersnReduced lung lesionnLess coughingnHigher cell-mediated immunitynExclusive Emunade adjuvantn1ml SQ/IM administration自桃艳锡稀行穴贵奴壮预貌咸魔慎业薛沧纤箭务主宽芬炊悉棍汽骋团碘倔猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择59叙妄缠羔乖合云獭凹钥伐王栋择湛酮丈旁收绎歹荐吵镣荆娃剃堕达氧懊析猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择M+PACTM 安百克Raising the standard in Mycoplasma Vaccines提高了支原体疫苗的标准蒂赎斑川晓力匙消稽掌殿左末母跳薛抹想肚奶典苟滦有碗窗晰尉儒瑚娥抉猪肺炎支原体的免疫时机及疫苗的选择猪肺炎支原体的免疫时机及疫苗的选择60