1、Philosophy of life and healthy 生命与健康的哲学What is a life?(什么是一个生命?)Drug screening strategy at post-genome era with Chinese Tradition Medicinal Theory 后基因时代药物筛选战略与中药学理论王晓明 副教授湖北中医药大学Sherman WangHubei University of Chinese Medicine The XXII World Congress of Philosophy(WCP 2008,Seoul,Korea)presentationDe
2、finition(定义):What is a life?(什么是一个生命?)Any a thing or a body with following characteristics(任何一个物质或物体具有如下特点)1.grow(生长)2.reproduce by itself(自我繁殖)3.can adjust and repair itself(可自我调节和修复)4.can be killed(no growth,no reproduce)(可被杀死)5.age to die(老死)1.grow 生长 small to big 小变大 infancy to youth 幼年至青年 (grow
3、th)成长期 2.reproduce by itself 自我繁殖 one to two 一个到二个 first genaration to second genaration 一代到二代 (mature)成熟期3.age to die 老死 after a period time 一段时间后 die:no growth,no reproduction 不能生长,不能繁殖 3.can adjust and repair itself (可自我调节和修复)4.can be killed(no growth,no reproduce)(可被杀死)life cycle 生命周期 1.birth 出生
4、,2.grow,生长 3.reproduce,繁殖 4.age to die 老死The difference conception betweenLife(生命):active,power,energy,活的,能量 process 过程Bioorganism(生命体,生物)structure,function Classification of Life 生命的分类Superkingdom:Prokarya(Prokaryotae)原核的单细胞(原核生物界);Kingdom:Bacteria(细菌界)Superkingdom:Eukarya(Eukaryotae)真核的单细胞(原生生物界);
5、Kingdom:Protoctista(formerly Protista)(真核的多细胞)Kingdom:Animalia(动物界)Kingdom:Plantae(植物界)Kingdom:Fungi (真菌界)Division;Class;Order;Family;Genus;Species Life Species 生命种类 Same species of life live on same energy and materials in same way 同一种类生命生存相同方式相同的能源和物质 Different species of life live on different sp
6、ace energy and materials.不同一种类生命生存在不相同的空间、能源和物质Life Type 生命类型 A species of life can differentiate to many different types of life 同一种生命种类可分化成不同类型生命 different types of life have different functions 不同类型生命有各自不同的功能 Life Level 生命层次 a level of life may be composed of many life types and/or life species一个
7、生命层次中可包含多种不同的生命类型 levels of life on same species 同种生命的层次 plant 植物 a cell 一个植物细胞,a strain一株植株,a group一个植物种群 animal 动物 a cell一个动物细胞,a body一个动物个体,a group 一个动物种群 man 人 a cell一个人细胞,a body 一个人体,a family 一个家庭,a compony一个公司,a city 一座城市 an ethnic 一个民族,a country 一个国家 a human?一个人类生命?(be becoming one life)正在逐渐形
8、成一个整体生命 levels of life on different species 不同种类生物的生命层次 an ecological system 一个生态体系 an ecological life Daniel A.Fiscus,The Ecosystemic Life Hypothesis an earth biosystem 一个地球生命体 an earth life James E.Lovelock,The Gaia Hypothesis Development of Life 生命的发展Life Species evolution 种类的进化(演化)Darwins Theory
9、 of Evolution,survival of the fittest 达尔文 生物进化论 适者生存 Life Type specialization 类型的特异化 survival of the strongest 强者生存 Life Level multiplication 层次的多重化 survival of the stablest 稳定生存 A Healthy life body(健康生命体)everything be balance(所有一切处于平衡状态)balance:inside 内部平衡 between inside and outside 内外平衡 生命的起源 orig
10、in of life first chemical balance of life 第一平衡 1 CO2+H2O H2CO3+GEnergy Production=Energy ConsumptionThe bigest chemical balance of life on earth 地球上生物生命最大的平衡CO2+H2O photosynthesis Plants grow+O2 光合作用 植物生长Plants+O2 animal digestion animal developing+CO2+H2O 植物 动物消化 动物演化A Unhealthy life body(不健康生命体)so
11、mething be unbalance in someplace(某种不平衡在某处)unbalance不平衡类型 biological disaster,calamity 生物灾难 species extinction物种灭绝 Organism 个体生命不平衡 metabolic unbalance 代谢失调(化学反应不平衡)cell growth irregulation细胞生长失调 What cause unbalance?(什么引起不平衡)1.outside factors(生命体外部因素)physics,chemicals,x-ray,heat,cold,shortage of re
12、sources,change of circumstance etc.2.other life invasion(其他生命侵入)unbalance can not be repaired by itself (不平衡生命体自生不能修复)we call disease(我们称为疾病)Need drug to treat(需要药物治疗)What is drug?(什么是药物)1.something that can treat disease.(restore balance)(可治疗疾病的物质或手段)2.out of a disease life(来源于疾病生命外)What kinds of f
13、unction a drug may be?(药物有哪几种功能)excite a balance activator 激动平衡 激动剂 depress a balance inhibitor 抑制平衡 抑制剂 stop a balance killer 终止平衡 阻断剂 Philosophy Puzzle(哲学问题)(The great challenge we face)(人类面临的巨大挑战)How and what kinds of drug we want to discover(怎样发现和发现何种药物可以the best treat a disease life and 最好的治疗疾病
14、生命,同时,the least hurt other lives?最小伤害其他生命Four question we will face 四个问题1.drug can treat disease(key unbalance)药物治疗最关键的不平衡2.drug can reach unbalace place 药物到达不平衡部位3.drug cannot disturb other balance 药物不能损坏其他平衡4.drug can treat the cause of disease (first unbalance)药物能够治疗第一个不平衡(引起疾病原因)drugFirst unbala
15、nceKey unbalance中药复方配伍理论 Chinese traditional theory of materia medica 药有君臣佐使,以相宣摄合和者药有君臣佐使,以相宣摄合和者 神农本草经 成书于战国时代,是我国现存最早的一部药物学专著。载药365种药物:植物药252味、动物药67味、矿物药46味。第一次从理论上阐述了我国药物学的知识。Ancient Chinese Doctor used drugs to treat a disease(Prescription)麻黄汤 Formula 组成 Ephedra herb 6g麻黄(君)cinnamon twig 4g桂枝(臣
16、)bitter apricot seed 9g杏仁(佐)licorice root 3g 甘草(佐使)Prescription:处方Formula:(组方)Monarch drug 君药 Minister drug 丞药 Assistant drug 佐药 Guide drug 使药Monarch drug:Can treat main problem(key unbalance)which may kill the disease life君药:治疗疾病的最关键的平衡Minister drug:Help Monarch drug arrive the disease (key unbalan
17、ce)place丞药:帮助君药到达疾病部位Assistant drug:Protect other lives which may be hurt by Monarch drug,Minister drug and Guide drug佐药:保护其他部位不被君药、使药伤害Guide drug:Find the factor that cause Disease(first unbalance)and treat it使药:治疗引起疾病的原因(第一个不平 衡)This is an explanation of Chinese traditional theory of materia medic
18、a in modern philosophy 这是中医药配伍理论的现代生物哲学诠释 This is Ancient Chinese Doctor gave us the great wisdom to treat a disease life这就是古代中医留给我们的伟大的策略智慧来拯救一个生病的生命The best drug to treat a disease life consists of the components or functions of Monarch drug,Minister drug,Assistant drug drug and Guide drug.What is
19、 the biggest life you can see?One earth,one lifeWhen will all lives on earth be extinction?Something be unbalance which can not be repaired by earth life itself Please love the earth life Keep everything be balance.All materials on earth surface are recycling Each life would be health and develop in harmony One life,one time We all share an earth life All of our lives belong to it敬请每一位有思辨能力的人思考:什么是你可以看见的最大的生命体?一个地球,一个目前已知最大的生命体,什么时候地球上所有的生命都会灭绝?当地球生命体内部某种不平衡而这个不平衡无法自我修复的时候 热爱地球这个生命体吧,使一切事物都保持平衡.所有的物质都循环再生每一个生命都会健康与和谐的发展每一个生命只有一次 一个地球生命是我们共同的生命,我们都属于这一个生命